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ZEB2 Antibody

ZEB2 Antibody

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Disponibilidad: Bajo pedido

0.01  (Excluded VAT) Tamaño: 0.1 mg

ZEB2 Antibody
ZEB2 Antibody

Catalog number: / Tamaño: / Precio: EUR (Excluded VAT)

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ZEB2 Antibody
ZEB2 Antibody

Catalog number: / Tamaño: / Precio: EUR (Excluding VAT)

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Proveedor: Gentaur
Disponibilidad: En orden
Número del catálogo: 223-5827-01mg
Descripción
ZEB2 Antibody: ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
Especificaciones
  • Research area: Cancer, Cell Cycle
  • Host species: Rabbit
  • Species reactivity: Human, Mouse, Rat
  • Homology: N/A
  • Immunogen: ZEB2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human ZEB2.
  • The immunogen is located within the last 50 amino acids of ZEB2.
  • Tested Applications: E, WB, ICC, IF
  • Applications: ZEB2 antibody can be used for detection of ZEB2 by Western blot at 1 - 2 μ
  • g/mL. Antibody can also be used for immunocytochemistry starting at 20 μ
  • g/mL. For immunofluorescence start at 20 μ
  • g/mL.
  • Antibody validated: Western Blot in mouse samples
  • Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
  • Specificity: ZEB2 antibody is predicted to not cross-react with ZEB1.
  • Positive control 1: Cat. No. 1287 - EL4 Cell Lysate
  • Positive control 2: Cat. No. 17-005 - Jurkat Cell Slide
  • Positive control 3: N/A
  • Positive control 4: N/A
  • Positive control 5: N/A
  • Positive control 6: N/A
  • Predicted molecular weight: Predicted: 134 kDa
  • Observed: 135 kDa
  • MW explanation: N/A
  • Validation: N/A
  • Isoforms: N/A
  • Purification: ZEB2 Antibody is affinity chromatography purified via peptide column.
  • Clonality: Polyclonal
  • Clone: N/A
  • Isotype: IgG
  • Conjugate: Unconjugated
  • Physical state: Liquid
  • Buffer: ZEB2 Antibody is supplied in PBS containing 0.02% sodium azide.
  • Concentration: 1 mg/mL
  • NCBI official symbol: ZEB2
  • Accession #: AAI27103
  • Protein GI #: 117558786
  • NCBI gene ID#: 9839
  • NCBI official full name: zinc finger E-box binding homeobox 2
  • NCBI organism: Homo sapiens
  • SWISSPROT #: O60315
Almacenamiento y envío
  • ZEB2 antibody can be stored at 4˚
  • C for three months and -20˚
  • C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Notas
Optimal dilutions for each application to be determined by the researcher.
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