APE1 (APEX1) (NM_080649) Human Recombinant Protein

APE1 (APEX1) (NM_080649) Human Recombinant Protein

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APE1 (APEX1) (NM_080649) Human Recombinant Protein
APE1 (APEX1) (NM_080649) Human Recombinant Protein

Catalog number: / Tamaño: / Precio: EUR (Excluded VAT)

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APE1 (APEX1) (NM_080649) Human Recombinant Protein
APE1 (APEX1) (NM_080649) Human Recombinant Protein

Catalog number: / Tamaño: / Precio: EUR (Excluding VAT)

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Proveedor: Gentaur
Disponibilidad: En orden
Número del catálogo: 519-PROTP27695
Descripción
Recombinant protein of human APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 3
Especificaciones
  • category: Recombinant Proteins
  • gene name: APEX1
  • contents: APEX1 Human solution (1mg/ml) containing 20mM Tris-HCl pH-8, 2mM DTT, 0.2M NaCl, and 10% glycerol.
  • uniprot_id: P27695
  • form: Sterile filtered colorless solution.
  • purification: Greater than 90% as determined by SDS-PAGE.
  • applications: Cell Culture
  • subcellular_localization: Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide (NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal (amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling. Ubiquitinated form is localized predominantly in the cytoplasm.
  • source: E. Coli
Almacenamiento y envío
Store at -80°C. Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Notas
this product is available in other size, 2ug, 10ug, 1mg, please contact us for more information.
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